⚡ Sustained Energy

NAD+ Precursors (NMN & NR)

NAD+ (nicotinamide adenine dinucleotide) is a critical coenzyme found in every cell that enables mitochondrial energy production. NAD+ levels decline by up to 50% by age 50. Precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) are converted into NAD+ in the body, restoring cellular energy metabolism. Studies show NMN supplementation improves muscle function, insulin sensitivity, and physical endurance in aging mice.

Mitochondrial Biogenesis

Compounds like CaAKG (calcium alpha-ketoglutarate) and 5-Amino-1MQ support the citric acid cycle and mitochondrial function. CaAKG extends lifespan in animal models and improves metabolic health. 5-Amino-1MQ inhibits an enzyme that slows mitochondrial production, effectively promoting new mitochondria formation.

Metabolic Optimization

Retatrutide, a triple hormone receptor agonist (GLP-1, GIP, glucagon), targets metabolic dysfunction at its root. By improving insulin sensitivity, reducing inflammation, and optimizing glucose metabolism, it addresses the metabolic underlying causes of age-related energy decline.

NAD+ and Aging: Research published in Cell Metabolism demonstrates that NAD+ levels decline with age across multiple tissues, and that restoring NAD+ through precursors improves mitochondrial function and extends lifespan in animal models. PMID: 30374161

NMN Clinical Trials: A human clinical trial published in Science showed that NMN supplementation is safe and increases blood NAD+ levels significantly in healthy adults. PMID: 35769013

CaAKG and Lifespan: Alpha-ketoglutarate supplementation has been shown to extend lifespan and healthspan in animal models, published in Cell Metabolism. PMID: 32719045

Retatrutide: Phase 2 trial results published in The New England Journal of Medicine showed retatrutide producing up to 24.2% weight loss and significant metabolic improvements. Phase 3 trials (TRIUMPH-Outcomes, TRANSCEND-T2D-3) are ongoing. PMID: 37266980